Spoiler
Does sleeping with Minthara, then breaking her neck, lock you out of other romances?
Is it possible to break her neck, then trigger Astarion’s romance scene later in Act I?
Can you romance Astarion/Shadowheart/Lae’zel in Act II after sleeping with Minthara?
A bit late to this but can confirm sleeping with her and then killing her does not affect other romances. In my Dark Urge playthrough I did this and then got with Lae’zel later.