This is so exciting. I worked in a lab where we were trying to do this, and so I was very aware what a gold rush we were in. I’m so glad to see that it’s actually happening.

This is truly a watershed moment in science. This is going to mark a major turning point in cellular medicine from theory to commonplace care. Eventually, this will end the pharma industry’s insulin cash cow.

But it’s even bigger than that. Because once we can engineer cells that produce a natural product, the next step is to engineer cells that produce synthetic medicines. Antidepressants, birth control, hormones, weight loss drugs, boner pills… The frontier is huge, lucrative, financially disruptive for pharma companies and life changing for patients. This is a big moment in history, and we all need to be fighting harder than ever to end for-profit healthcare. Otherwise we’re going to end up with subscription licenses to our own bodies.

This article doesn’t really answer most of my questions.

What subjects does the AI cover? Do they do all their learning independently? Does AI compose the entire lesson plan? What is the software platform? Who developed it? Is this just an LLM or is there more to it? How are students assessed? How long has the school been around, and what is their reputation? What is the fundamental goal of their approach?

Overall, this sounds quite dumb. Just incredibly and transparently stupid. Like, if they insisted that all learning would be done on the blockchain. I’m very open minded, but I don’t understand what the student’s experience will be. Maybe they’ll learn in the same way one could learn by browsing Wikipedia for 7 hours a day. But will they enjoy it? Will it help them find career fulfillment, or build confidence or learn social skills? It just sounds so much like that Willie Wonka experience scam but applied to an expensive private school instead of a pop-up attraction.

I was trying to explain what AI alignment is to my mom, and I ended up using the behavior of companies like OpenAI, and how they’re distorted by profit motive as an example of a misaligned decision making system. And I realized that late stage capitalism is basically the paperclip maximizer made real.

This is a very good article. I think AI models have more to teach us about epistemology than people want to believe right now.

Hard to really say, but I would venture that the best way to tell was from what he did with the attention.

I doubt it’s as simple as ‘He did it for the money’ or ‘He did it for the clicks’ etc. I’m guessing he did it for all the attention/money/influence it got him. I think as we confront a world where AI can be used to fabricate people with incredible ease, the lesson is that people need to occasionally meet in person if we want to guarantee that they have a physical personhood.

That sounds like some very cool engineering. I hope it sees as little use as possible, but I’m glad you’re prepared.

I’m concerned that this would require a continuous supply of water at a flow rate that might not be realistic.

I will also add that I think in the long run, as we try to figure out how to differentiate between humans and machines, the only real reliably solution I see is to focus on elevating the individual. Having people with long histories validate their reality by living and documenting it.

I don’t upvote something that I’d be ashamed for someone to see I upvote. I might make an exception for pornographic content, but even with that, if it’s pseudononymous in that it’s not attached to my personal public life, I don’t mind if someone can trace through and see what a specific account I use for those purposes has liked and disliked.

I don’t think it’s secret. A lot of OpenAI’s business strategy is to warn of the danger of their own project as a means of hyping it.

OpenAI, despite having produced a pretty novel product, doesn’t really have a sound business model. LLMs are actually expensive to run. The energy and processing is not cheap, and it’s really not clear that they produce something of value. It’s a cool party trick, but a lot of the use cases just aren’t cost effective at this point. That makes their innovation hard to commercialize. So OpenAI promotes itself like online clickbait games.

You know the ones that are like, ‘WARNING: This game is so sexy it is ADDICTIVE! Do NOT play our game if you don’t want to CUM TOO HARD!’

That’s OpenAI’s marketing strategy.

They start at $70k. And they are actually still losing money on each sale.

It’s largely marketed as a recreation/sport vehicle. It’s for going camping and off-roading.

That isn’t too say that it can’t also get you to and from work, or even be used for constructive uses. But at the price and feature set, I think anyone would agree it’s designed to be a fun luxury first and foremost rather than a practical tool.

Whew. I’m glad he’s happy with his purchase. I can’t ever imagine having enough money that I could drop that kind of cash on a toy, no matter how neat I think it looks.

Haha a bike.

I hold out hope, actually, that as the right-to-repair movement continues to grow, eventually repairability and control will become more common consumer interests, in the same way that vehicle safety wasn’t something people thought about when buying a car before the 70s, and now it’s one of the main influences when buying a car.

Once people start caring – and again, I believe this is the direction we’re heading – it will become something manufacturers have to design for.

This is modestly interesting. My brother worked here before they had layoffs about two years ago, and had a generally favorable opinion of the company and leadership.

Fundamentally, while I think RJ seems like a sound businessman and technologist, and I like the company’s taste a bit, I will never be able to reconcile his views with mine. He very openly views cars as computers and software and services that happen to move you around, and I would like it to be a machine over which I have as minimal a relationship as possible with the manufacturer after I acquire the product.

Still, I wish them luck.

This is actually a misrepresentation of the law.

The law bans school districts from requiring teachers to report if students start experimenting with different pronouns.

Teachers can still report this to parents. There is nothing barring them from doing so. The only change is that they aren’t policed by their school district.

Technically, this is actually the classically conservative position!

This whole thing is extremely stupid. Parents should take care of their own shit. You want to know what your kid is thinking? Talk to them. Demanding that the trusted adults in their lives who DO pay attention to them narc for you is a weak-ass move for parents who run to the nanny state to help them raise their kids because they don’t know how to manage their own damn family life.

That’s great. I wish all this stuff was more accessible to watch.

Agree 100%

I agree with that. Looking through, I find understanding the basic rules to be kind of a burden. It took me a while to realize that “Operations” is the rules section.

I think it makes sense to show players the character sheet early, because that’s the nexus through which they really experience the game. I like the demo scene towards the beginning, but I think a quickstart guide to explain basic rules to the players very, VERY clearly is usually a good idea.

Still, I’m continuously impressed at how well this adapts Star Trek to an RPG. I was initially skeptical that an RPG could take all the nonsense we see in decades of different shows and create a cohesive basis for all of it, but this is really impressive. I’d have to play to see if the rules feel balanced and natural, but at a glance, they make far more sense than plenty of other RPGs I’ve seen. I think this looks like a really fun game.

I spent a while reading through this, and I gotta say that this is a really good RPG book. It’s very thorough, it’s well written for suggesting ways to play, it’s attractively formatted. This is a cool book.

Oh wow, thanks for the heads up!

I’m excited to check this out.

I think maybe execs and investors might feel it’s all the same, but if you’re a project manager for cloud infrastructure for enterprise services or you’ve been working for years on releasing a new component of Bing search that you think is a real gamechanger and some muckity-muck at the top says, ‘Oh, don’t worry about that anymore: a property manager that’s owned by a private equity partner of one of our big investors wants the chatbot that schedules apartment viewings in Huntsville to be more flirty, so go massage the prompts to make it convincingly laugh at bad jokes,’ some of those folks are liable to start grumbling that this isn’t the role that they were pitched when they took this job.